Semaglutide Dosage Guide for Weight Loss

How to Use It Safely and Effectively

Looking to lose weight without the crash diets and endless cardio? Semaglutide has quickly become a game-changing solution for medically assisted weight loss. Originally developed for type 2 diabetes, this once-weekly injectable is now widely used for body composition goals—and with the right dosage, it can help support steady, sustainable fat loss.

Here’s your full guide to how semaglutide is typically dosed, what to expect at each stage, and how to get the most out of your treatment.

What is Semaglutide?

Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist. It mimics a natural hormone that regulates appetite, insulin, and glucose levels. By delaying stomach emptying and reducing hunger signals, semaglutide helps you eat less without feeling deprived.

It is typically prescribed for people with type 2 diabetes or those who are overweight or obese and seeking long-term weight management support.

Available Dosage Strengths

Semaglutide is administered via once-weekly subcutaneous injection, and comes in a variety of dose strengths:

• 0.25 mg (starting dose)

• 0.5 mg

• 1 mg

• 1.7 mg

• 2.0 mg (maximum maintenance dose in diabetes patients)

• 2.4 mg (approved maintenance dose for weight loss)

Semaglutide Titration Schedule for Weight Loss

The body needs time to adjust to semaglutide. Starting with a lower dose reduces the risk of side effects like nausea, vomiting, and fatigue.

Common Dose Escalation Plan:

Note: This schedule may vary depending on individual response. Your provider may keep you on a lower dose longer if you experience side effects.

When and How to Inject

• Once per week, same day each week

• Inject subcutaneously into the abdomen, thigh, or upper arm

• Rotate injection sites each week to prevent irritation

What to Expect

Most people experience reduced appetite and food cravings within the first 1-2 weeks.

Weight loss typically becomes noticeable after the first month, and continues as doses increase. By the time you reach the 1.7 mg or 2.4 mg doses, weight loss often becomes more significant.

Tips for Best Results

• Pair with a high-protein, nutrient-rich diet to support lean muscle and satiety

• Stay hydrated, especially if experiencing nausea

• Add light daily movement like walking to enhance metabolic function

• Avoid overeating on non-hungry days just because you feel less full

Side Effects to Watch Out For

Most are mild and manageable, especially if doses are increased gradually.

• Nausea

• Constipation

• Fatigue

• Headaches

• Burping or bloating

• Low blood sugar (rare)

If these persist or worsen, speak to a healthcare provider. Serious side effects are rare, but may include pancreatitis or gallbladder issues.

What to Do If You Miss a Dose

• If it’s been less than 5 days since your missed dose, take it as soon as you remember

• If it’s been more than 5 days, skip the missed dose and resume your regular schedule

• Do not take two doses within 3 days of each other

Can You Change Injection Days?

Yes. You may shift your injection day if needed, as long as there are at least 48 hours between doses.

Final Thoughts

Semaglutide offers a powerful, science-backed tool for people serious about long-term weight loss. With gradual dosing and patience, many experience meaningful fat loss, better blood sugar balance, and reduced food cravings.

Always consult with a healthcare provider before starting semaglutide, especially if you have a history of thyroid problems, pancreatitis, or are taking other medications.

DISCLAIMER: This content is for informational purposes only and does not substitute medical advice. Always consult with a licensed professional before starting any medication or weight loss regimen.